Annals of Oncology: Official Journal of the European Society - download pdf or read online

By Brian L. Samuels, John E. Ultmann (auth.), John E. Ultmann, Brian L. Samuels (eds.)

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34 Table 1. Ig light chain staining and IgL-mRNA in HSR cells in Hodgkin's disease. No. of cases 11 7 1 3 Paraffin sections K f.. + + + + Frozen sections mRNA K K + + Table 3. Absence of antigenic relationship between HSR cells and interdigitating cells (IDC). Marker/ molecule + K and A in paraffin sections represents a fixation artifact in most instances, probably due to passive penetration of serum immunoglobulins into the tumor cells during formol fixation. (2) Monoclonal expression of Ig light chains can be masked by passive uptake of serum polyclonal IgG during fixation.

T 2 variation was slightly increased in the two patients with positive bone marrow biopsies, but mean LV bone marrow T 2 overlapped with controls (Fig. 3). 11500 t- 1000 I 1500 Post-tceatment Pre-treatment Biopsy-negative Hodgkin's disease Eighteen patients had no evidence of bone marrow involvement by lymphoma on bilateral iliac crest bone marrow biopsy. Four of these 18 patients had quantitative abnormalities of the LV bone marrow, either elevated mean LV bone marrow T 1 and/or increased T 1 variation.

Electron microscopic aspects of Hodgkin's disease. J Cancer Res Clin Oneal 1981; 101: 135148. Hsu SM, Yang K, Jaffe ES. Phenotypic expression of Hodgkin and Reed-Sternberg cells in Hodgkin's disease. Am J Pathol 1985;118:209-21~ * Data from Diehl et al. [33]. lymphomas (especially the so-called HD-related ALC lymphoma type) to HD remains to be determined. The chromosomal breakpoints seen in three cases of Ki-1 + ALC lymphomas of B-cell type were also encountered in some cases of HD (Table 7). Acknowledgment The authors thank Mr.

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