New PDF release: Adhesion in Leukocyte Homing and Differentiation

By F. Melchers (auth.), Dominique Dunon Ph.D., Charles R. Mackay Ph.D., Beat A. Imhof Ph.D. (eds.)

This quantity of present issues in Microbiology and Immunology used to be deliberate in parallel with an EM BO workshop on cell-cell Interactions in Leukocyte Homing and Differentiation held on the Basel Institute for Immunology in November 1992, and lots of of the workshop audio system have contributed to it. telephone adhesion is likely one of the so much dynamic fields of organic learn and provided during this ebook is the present wisdom at the constitution and serve as of the foremost households of telephone adhesion molecules-the integrins, the selectins, the immunoglobulin superfamily, and CD44. advanced interactions among the participants of those households mediate varied adhesion features, together with leukocyte-leukocyte interactions, lymphocyte homing, irritation, and lymphocyte-stromal mobilephone interplay in the course of hematopoiesis. loads of emphasis is put on the regulatory components that keep an eye on the expression and serve as of adhesion molecules. Cytokines not just set off the expression of convinced adhesion molecules, yet can also alter their practical prestige. for example, the integrins exist in both an inactive nonfunctional shape or an energetic practical shape, and a couple of intracellular or extracellular stimuli adjust integrin functionality. this can be relatively vital in the course of leukocyte binding to endothelium and transendothelial migration, which proceeds via a cascade of adhesion occasions. even though mobile adhesion molecules play an immense function in lots of strategies, this publication concentrates on their position in the immune method. a couple of chapters speak about the migration of lymphocytes among hematopoietic organs resembling the thymus, lymph nodes, Peyer's patches, and spleen.

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39 4 Structure/Functional Relationships. . . . . . . . . . . . . . . . . . . . . 40 5 Potential In Vivo Functions ................................................ 41 6 Summary ............................................................... 43 References ................................................................ 43 1 Historical Background Beginning in the mid-1980s, a number of groups working independently began to serologically characterize a series of vascular cell surface proteins that were subsequently designated as the CD-31 antigen.

These data suggest that PECAM -1 may playa role in vascular wound healing and angiogenesis. Consistent with these findings are studies on PECAM-1 expression during murine cardiac morphogenesis (BALDWIN et al. 1992). PECAM-1 mRNA has been found in presomite (7 day) mouse embryos during the initiation of vascular development. 5 days) that persisted throughout development. However, PECAM-1 could not be detected on endocardial cells undergoing mesenchymal transformation in the atrioventicular canal.

Geha RS, Arnaout MA (1989) Constitutive and stimulus-induced phosphorylation of CD11 ICD18 leukocyte adhesion molecules. J Cell Bioi 109: 3435-3444 26 A. Sonnenberg Cheng Y -F, Clyman RI, Enenstein J, Waleh N, Pytela R, Kramer RH (1991) The integrin complex IXvP3 participates in the adhesion of microvascular endothelial cells to fibronectin. Exp Cell Res 1 94: 69-77 Cheresh DA. Pierschbacher MD, Herzig, MA, Mujoo K (1986) Disialogangliosides GD2 and GD3 are involved in the attachment of human melanoma and neuroblastoma cells to extracellular matrix proteins.

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